Figure 2.

Specific cell association of ¹²⁵I-labeled LDL, AcLDL, and OxLDL with wild-type and SRA knockout macrophages at 15°C. Macrophages were incubated for 2 hr with 2.5 μg ¹²⁵I-labeled ligand in the presence or absence of 30-fold excess unlabeled ligand. Values shown are the mean of two determinations ± SD in a representative experiment. The experiment was done three times and gave similar results. Nonspecific binding of the label is subtracted. ∗, P = 0.019; ∗∗, P = 0.139.