Figure 3.

Cell line specificity and dose–response activity of ODNs targeting the N regions of DOHH2 (A and C) and of DHL-4 (B and D) cells. Phosphorothioate sense ODN n1 (A) and ODN n4 (B) were given as a single dose of 10 μM on day 0. Control ODN were the phosphorothioate antisense ODN n1 or ODN n4, respectively. Dose–response activity of ODN n1 (C) or of ODN n4 (D) is shown. Cell count and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assays were done on day 5. Data, expressed as the viable cell index (48), are the mean ± SEM of three experiments. ∗, P < 0.01.