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ELISA measurements of serum FGF-23, MEPE, and sFRP-4 levels demonstrated that all 3 phosphatonins were increased in hyp- and Cre-PhexΔflox/y mice. However, serum FGF-23, but not MEPE or sFRP-4, was increased in OC-Cre-PhexΔflox/y mice. **P < 0.01, ***P < 0.001 compared with corresponding normal mice.
