Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Functional negative coupling to adenylate cyclase. Subtype-selective opioid receptor agonists were tested for their ability to inhibit forskolin-stimulated cAMP accumulation in HEK 293 cells expressing the C. commersoni μ-opioid receptor (filled bars) and in nontransfected cells (striped bars). Cells were incubated in the presence of 16 nM forskolin (FSK) alone or together with either DAMGO (1 μM), DAMGO (1 μM) plus naloxone (10 μM), naloxone (10 μM), U50488 (1 μM), or DPDPE (1 μM).
