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Effects of spinal nNOS antisense A treatment on morphine analgesia. Groups of mice (n = 20–30) received saline, antisense A (5 μg, i.t.) or mismatch A (5 μg, i.t.) and were tested at the indicated time with systemic morphine (5 mg/kg, s.c.). Systemic morphine analgesia was significantly lowered only after 1 (P < 0.03) and 3 (P < 0.001) days.
