Table 1.
Conditions | EC50, μM
|
||
---|---|---|---|
Rabbit anococcygeus muscle | Human corpus cavernosum | Rat anococcygeus muscle | |
Control | 1.8 ± 0.3 | 56.1 ± 6.2 | 19.4 ± 1.9 |
During EFS | >300* | >300* | 20.8 ± 1.2 |
During EFS +l-NOARG | 1.7 ± 0.3 | 48.3 ± 2.7 | 19.6 ± 1.0 |
EC50 values for noradrenaline-induced contractions under control conditions, during EFS, and during EFS after l-NOARG (300 μM) treatment in tissues treated with guanethidine (10 μM).
P < 0.001 vs. control value; n = 4 for each. Where values are >300 μM, the EC50 was considered to be 300 μM for statistical comparison.