Table 1.
QTLs for halothane sensitivity
| Nearest marker | Assay | Mean EC50 RIs, vol
%*
|
F ratio | P value† | % Vp | Location, map units‡ | |
|---|---|---|---|---|---|---|---|
| BO allele | N2 allele | ||||||
| stP124 (IC) | Dispersal | 1.12 ± 0.12 | 0.69 ± 0.05 | 16.8 | 0.0001 | 22 | 0.4 |
| stP6 (VR) | Dispersal | 0.58 ± 0.05 | 1.01 ± 0.07 | 23.2 | 0.000008 | 42 | 5.9 |
| stP18 (VR) | Mating | 0.46 ± 0.02 | 0.66 ± 0.02 | 53.7 | 0.000000003 | 48 | 9.7 |
| stP124 (IC) × stP98 (IIC) | Mating | NA | NA | 23.4 | 0.00003 | 11 | NA |
| bP1 (VC) × stP129 (XC) | Mating | NA | NA | 32.9 | 0.000003 | 16 | NA |
*
Mean ± SEM of the EC50s for all strains with either the BO or the N2 allele at that marker.
†
Bonferroni-corrected significance thresholds are 0.05/11 = 0.0045 for single QTL and 0.05/55 = 0.0009 for interacting QTLs. Only single QTLs that are also significant at the 0.05 level by experiment-wise permutation are listed. The F ratios/P values for the interacting QTLs are for the interaction term of the regression equation.
‡
Location of the peak likelihood ratio by interval mapping relative to the standard C. elegans genetic map.
NA, not available.