Figure 6.

(a) A plot of the hydrogen bond that developed between the 2′-hydroxyl groups of residues U_16.1 and C₁₇. The 2′-hydroxyl group of U_16.1 may assist in the formation of NACs by helping to orient the 2′-hydroxyl of C₁₇ for attack. (b) Plot of the hydrogen bond that formed between A₁₄ and A_15.1. Notice that this bond formed after 400 ps total simulation time and appears to precede the formation of the hydrogen bond mentioned in a. (c) A plot of the hydrogen bond between H41 of residue C15.2 and O2P of residue A14 with an average distance of 2.22 Å.