Figure 7.

The effects of Adiol on the transcriptional activity of different steroid receptors. DU145 cells were cotransfected with 1.5 μg receptor and 3.5 μg of its reporter (AR/MMTV-CAT, progesterone receptor (PR)/MMTV-CAT, glucocorticoid receptor (GR)/MMTV-CAT, ER/ERE-CAT) with or without 4.5 μg ARA70, and treated with ligand [1 nM DHT, 10 nM progesterone (P), 10 nM dexamethasone (Dex), or 10 nM E2] or increasing concentrations of Adiol. Values represent the means ± SD of at least three determinations.