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Formation of base propenal following radical-mediated 4′-hydrogen atom abstraction (15). (A) The pathway leading to base propenal is oxygen dependent for both calicheamicin and bleomycin, while the oxidized abasic site produced by bleomycin is oxygen independent (33). (B) A model for the formation of M1G in DNA by reaction of base propenal (cytidine) with a neighboring guanine.
