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Proposed model for leading and lagging strand holoenzyme complex formation. Both leading and lagging strand holoenzymes are composed of the T4 polymerase complexed with a 45 “sliding clamp” protein. The formation of a stoichiometric replication complex is dependent on the presence of the T4 DNA primase, rNTPs, and a primase recognition site. The leading and lagging strand holoenzymes are proposed to interact via an internal region protrusion.
