Figure 1.

[³H]Thymidine incorporation response to IGF-I and echistatin. Quiescent pSMCs cultures were stimulated with increasing concentrations of IGF-I (•—•) and the amount of [³H]thymidine that was incorporated into DNA determined as described in Materials and Methods. Additional cultures also were exposed to echistatin 10⁻⁷ M (□—□) plated on vitronectin (2.0 μg/well) (■—■) or plated on vitronectin and exposed to echistatin (○—○). Each point represents the mean of triplicate determinations.