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. 1999 Oct 4;147(1):59–70. doi: 10.1083/jcb.147.1.59

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Visualization of NT-3–stimulated β-actin mRNA localization in cells treated with cytoskeletal disrupting drugs. (A) β-actin mRNA localization in cytochalasin-D–treated cell. Hybridization signal was prominent in the cell body (arrow) and localized in granules within growth cones (arrowhead). (B) Disruption of F-actin in growth cones by cytochalasin-D. Note the absence of filamentous staining in growth cone (arrowhead). (C) In colchicine-treated cells, β-actin mRNA was not accumulated within growth cones in response to NT-3. (D) Lack of filamentous staining for tubulin was also observed in growth cones (arrowhead). There was no evidence that growth cones were collapsed by either drug. Quantitative analysis of growth once area failed to show any statistically significant reduction in size after 30-min exposures.

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