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. 1998 Sep 15;95(19):11412–11417. doi: 10.1073/pnas.95.19.11412

Figure 4.

Figure 4

BDNF regulates spontaneous mIPSCs in cultured hippocampal neurons. (a) mIPSCs recorded for 1 sec in control, BDNF treated, RAS, and AS oligonucleotide-treated cultures. Note the difference in size and frequency of mIPSCs in the different conditions. (b) Total number of events in 10-sec recording intervals for all of the cells recorded in the study (n = 6 for control, n = 8 for BDNF, n = 6 for RAS, and n = 14 for AS). The BDNF group had significantly higher rates of spontaneous mIPSC discharges, and the AS group had significantly lower rates of discharges (ANOVA followed by individual t tests; ∗, P < 0.01). (c) Cumulative histograms of the mIPSCs sizes in the four groups: left, control and BDNF; right, RAS and AS. BDNF produced significantly larger mIPSCs than the corresponding control group (t = 4.54, P < 0.01) whereas there was no difference in size of mIPSCs between the AS and RAS groups.