Figure 1.

Effects of chronic (21-day) administration of antipsychotic drugs on NT release. Values are expressed as a percentage of the control group for graphic representation. Basal values (expressed as picograms of NT per hour±SEM) of the vehicle control group for each of the three major experiments were: A. haloperidol, striatum: 10.98 ± 3.40 (n = 7); nucleus accumbens: 4.34 ± 0.69 (n = 6); B. clozapine, striatum: 10.36 ± 0.80 (n = 5); nucleus accumbens: 2.94 ± 0.40 (n = 5); C. olanzapine, striatum: 8.85 ± 0.60 (n = 6); nucleus accumbens: 2.15 ± 0.03 (n = 6). Haloperidol increased NT release in both the caudate-putamen and the nucleus accumbens. Olanzapine and clozapine increased NT release only in the nucleus accumbens.