Figure 1.

Activation of muscarinic receptors potentiates NMDA-receptor currents in CA1 pyramidal cells. Bath application of 10 μM CCh induces a marked potentiation of currents evoked by NMDA application. (A) Single traces obtained before CCh application (Pre-Drug), at the peak of CCh-induced potentiation (10 μM CCh), and after a 5-min washout. (B) The time course of CCh-induced potentiation of NMDAR currents demonstrates that this effect quickly desensitizes. Data represent mean ± SEM of five cells. (C) The potentiating effect of CCh is dose-dependent in the range of 1–100 μM. Data represent mean ± SEM of peak potentiation with three cells for each data point.