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m1-Toxin specifically inhibits the CCh-induced potentiation of NMDA-receptor currents. (A) Time course of CCh-induced potentiation of NMDAR current in a representative cell pretreated with m1-toxin (○) and a control cell treated in the same fashion but without m1-toxin (•). (B) Mean (±SEM) data demonstrating that m1-toxin specifically blocks the potentiating effect of CCh but has no effect on the response to 1S,3R-ACPD. (∗, P < 0.05; n = 4–5 for each condition).
