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. 1965 Jun 26;1(5451):1632–1635. doi: 10.1136/bmj.1.5451.1632

Clinical Trial of Epsilon-aminocaproic Acid in Severe Haemophilia

A M Gordon, G P McNicol, Anne HC Dubber, G A McDonald, A S Douglas
PMCID: PMC2167050  PMID: 14295319

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABLONDI F. B., HAGAN J. J., PHILIPS M., DE RENZO E. C. Inhibition of plasmin, trypsin and the streptokinase-activated fibrinolytic system by 6-aminocaproic acid. Arch Biochem Biophys. 1959 May;82(1):153–160. doi: 10.1016/0003-9861(59)90100-6. [DOI] [PubMed] [Google Scholar]
  2. ALKJAERSIG N., FLETCHER A. P., SHERRY S. xi-Aminocaproic acid: an inhibitor of plasminogen activation. J Biol Chem. 1959 Apr;234(4):832–837. [PubMed] [Google Scholar]
  3. ANDERSSON L., NILSSON I. M. Effect of 6-amino-n-caproic acid (6-ACA) on fibrinolysis and bleeding conditions in prostatic disease. Acta Chir Scand. 1961 May;121:291–298. [PubMed] [Google Scholar]
  4. ANDERSSON L., NILSSON I. M., OLOW B. Fibrinolytic activity in man during surgery. Thromb Diath Haemorrh. 1962 Jul 15;7:391–403. [PubMed] [Google Scholar]
  5. ASTRUP T. The biological significance of fibrinolysis. Lancet. 1956 Sep 15;271(6942):565–568. doi: 10.1016/s0140-6736(56)92048-7. [DOI] [PubMed] [Google Scholar]
  6. BARKHAN P. HAEMATURIA IN A HAEMOPHILIAC TREATED WITH E-AMINOCAPROIC ACID. Lancet. 1964 Nov 14;2(7368):1061–1061. doi: 10.1016/s0140-6736(64)91010-4. [DOI] [PubMed] [Google Scholar]
  7. BECK E., SCHMUTZLER R., DUCKERT F. INHIBITION OF FIBRINOLYSIS AND FIBRINOGENOLYSIS IN MAN: COMPARISON OF EPILSON-AMINOCAPROIC AID AND KALLIKREIN INHIBITOR. Thromb Diath Haemorrh. 1963 Nov 1;10:106–119. [PubMed] [Google Scholar]
  8. BELL W. N., ALTON H. G. A brain extract as a substitute for platelet suspensions in the thromboplastin generation test. Nature. 1954 Nov 6;174(4436):880–881. doi: 10.1038/174880a0. [DOI] [PubMed] [Google Scholar]
  9. DUBBER A. H., MCNICOL G. P., DOUGLAS A. S., MELANDER B. SOME PROPERTIES OF THE ANTIFIBRINOLYTICALLY ACTIVE ISOMER OF AMINO-METHYLCYCLOHEXANE CARBOXYLIC ACID. Lancet. 1964 Dec 19;2(7373):1317–1319. doi: 10.1016/s0140-6736(64)91108-0. [DOI] [PubMed] [Google Scholar]
  10. FLETCHER A. P., ALKJAERSIG N., SHERRY S. Fibrinolytic mechanisms and the development of thrombolytic therapy. Am J Med. 1962 Nov;33:738–752. doi: 10.1016/0002-9343(62)90251-6. [DOI] [PubMed] [Google Scholar]
  11. GANS H., KRIVIT W. Problems in hemostasis during openheart surgery. III. Epsilon amino caproic acid as an inhibitor of plasminogen activator activity. Ann Surg. 1962 Feb;155:268–276. doi: 10.1097/00000658-196200000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. GROSSI C. E., MORENO A. H., ROUSSELOT L. M. Studies on spontaneous fibrinolytic activity in patients with cirrhosis of the liver and its inhibition by epsilon amino caproic acid. Ann Surg. 1961 Mar;153:383–393. doi: 10.1097/00000658-196103000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MCNICOL G. P., DOUGLAS A. S. EPSILON-AMINOCAPROIC ACID AND OTHER INHIBITORS OF FIBRINOLYSIS. Br Med Bull. 1964 Sep;20:233–239. doi: 10.1093/oxfordjournals.bmb.a070338. [DOI] [PubMed] [Google Scholar]
  14. MCNICOL G. P., GALE S. B., DOUGLAS A. S. In-vitro and in-vivo studies of a preparation of urokinase. Br Med J. 1963 Apr 6;1(5335):909–915. doi: 10.1136/bmj.1.5335.909. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. NAEYE R. L. Thrombotic state after a hemorrhagic diathesis, a possible complication of therapy with epsilon-aminocapproic acid. Blood. 1962 Jun;19:694–701. [PubMed] [Google Scholar]
  16. RATNOFF O. D., MENZIE C. A new method for the determination of fibrinogen in small samples of plasma. J Lab Clin Med. 1951 Feb;37(2):316–320. [PubMed] [Google Scholar]
  17. RAUSEN A. R., CRUCHAUD A., McMILLAN C. W., GITLIN D. A study of fibrinogen turnover in classical hemophilia and congenital afibrinogenemia. Blood. 1961 Dec;18:710–716. [PubMed] [Google Scholar]
  18. REID W. O., LUCAS O. N., FRANCISCO J., GEISLER P. H., ERSLEV A. J. THE USE OF EPSILON-AMINOCAPROIC ACID IN THE MANAGEMENT OF DENTAL EXTRACTIONS IN THE HEMOPHILIAC. Am J Med Sci. 1964 Aug;248:184–188. doi: 10.1097/00000441-196408000-00007. [DOI] [PubMed] [Google Scholar]
  19. REMMERT L. F., COHEN P. P. Partial purification and properties of a proteolytic enzyme of human serum. J Biol Chem. 1949 Nov;181(1):431–448. [PubMed] [Google Scholar]
  20. SHERRY S., ALKJAERSIG N. Studies on the fibrinolytic enzyme of human plasma. Thromb Diath Haemorrh. 1957 Aug 15;1(2):264–288. [PubMed] [Google Scholar]
  21. SHERRY S., FLETCHER A. P., ALKJAERSIG N. Fibrinolysis and fibrinolytic activity in man. Physiol Rev. 1959 Apr;39(2):343–382. doi: 10.1152/physrev.1959.39.2.343. [DOI] [PubMed] [Google Scholar]
  22. STEIGER B., WHITE J. G., KRIVIT W. Epsilon-amino-caproic acid for hematuria in hemophilia. J Lancet. 1962 Oct;82:421–424. [PubMed] [Google Scholar]

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