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. 1998 Sep 29;95(20):11549–11554. doi: 10.1073/pnas.95.20.11549

Figure 3.

Figure 3

Association and dissociation of telomerase and 2′-O-meRNA 1. (A) Rate of telomerase inhibition upon addition of 2′-O-meRNA 1. 2′-O-meRNA 1 (333 nM) was added to telomerase-containing cell extract for the time indicated (0, 0.5, 1, 3, 5, 8, or 10 min) before initiation of strand elongation. (B) Stability of inhibition by 2′-O-meRNA 1. Telomerase was incubated with 100 nM 2′-O-meRNA 1 for 30 min to ensure complete inhibition. Competitor DNA (5.0 μM final concentration) complementary to 1 was then added for 0, 10, or 20 min before the assay for telomerase activity.