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Drug sensitivity phenotypes associated with the Q66K alteration in C. trachomatis L2 ribosomal protein L4
| C. trachomatis L2 strain | MIC (μg/ml) of:
|
||||||
|---|---|---|---|---|---|---|---|
| AZM | ERY | JOS | SPI | CLI | VIR | CLM | |
| Wild type | 0.1 | 0.2 | 0.05 | 0.8 | 0.125 | 4 | 0.4 |
| L2AZM#23a | 0.8 | 0.8 | 0.2 | 4 | 0.5 | 8 | 0.4 |
| L2AZM#31b | 0.8 | 0.8 | 0.2 | 4 | 0.5 | 8 | 0.4 |
Twenty-three passages in various concentrations of AZM (up to 50 ng/ml).
Twenty-eight passages with up to 100 ng/ml AZM followed by three expansions without AZM.
