TABLE 1.

Final fitted gatifloxacin pharmacokinetic parameter estimates for mice

Parametera	Units	Estimate
Vc/F	Liters/kg	0.20
Vp/F	Liters/kg	1.6
CLD/F	Liters/h/kg	7.7
CLT/F	Liters/h/kg	2.7
Ka	h−1	11.0
tlag	h	0.23
t1/2	h	0.60

^aV_c/F, apparent volume of distribution in the central compartment; V_p/F, apparent volume of distribution in the peripheral compartment; CL_D/F, apparent distributional clearance; CL_T/F, apparent total clearance; K_a, absorption rate constant; t_lag, lag time; t_1/2, half-life.