TABLE 2.
Effects of various drugs on B. mandrillaris-mediated cytopathogenicity in HBMEC
| Treatment | Mean % cytopathogenicity in HBMEC ± SE |
|---|---|
| None (amoebae alone) | 74 ± 4.5 |
| Cytochalasin D | |
| 10 μM | 64.7 ± 4.5 (13)a |
| 50 μM | 43 ± 5.5 (42) |
| Cycloheximide | |
| 100 μM | 41.3 ± 4 (44) |
| 200 μM | 81.4 ± 3.7 (0) |
| Clindamycin | |
| 5 μg/ml | 62.2 ± 5.9 (16) |
| 10 μg/ml | 66.4 ± 2.1 (10) |
| Flucytosine | |
| 5 μg/ml | 59.5 ± 3.5 (20) |
| 10 μg/ml | 29 ± 2.8 (61) |
| Artemisinin | |
| 5 μg/ml | 48.6 ± 8.5 (34) |
| 10 μg/ml | 40.4 ± 2.8 (45) |
| Ketoconazole | |
| 5 μg/ml | 64 ± 2.8 (14) |
| 10 μg/ml | 8.5 ± 2.7 (88.5) |
a
Values in parentheses indicate percent inhibition of cytopathogenicity in HBMEC.