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Sequence analysis of QRDR for resistant mutants
| Day of CFU count | No. of resistant mutants isolated at MXF concn (μg/ml) of:
|
Mutation in:
|
|||
|---|---|---|---|---|---|
| 0.5 | 2 | 8 | gyrA | gyrB | |
| 28a | D94N | None | |||
| 42 | 2 | 2 | 0 | None | E512D |
| 56 (mouse 1) | 8 | 4 | 0 | D94N | None |
| 56 (mouse 2)a | D94N | None | |||
| 56 (mouse 3)a | None | E512D | |||
Performed with isolates obtained on plates by the indirect method.
