TABLE 1.
Summary of TLR4 SNPs tested for association with PT-IgG values
| SNPa | Minor allele frequency |
P value
|
Allele | No. of children with genotype | Ln(PT-IgG) titerd | PT-IgG titer (U/ml) | |
|---|---|---|---|---|---|---|---|
| Continuousb | Percentilec | ||||||
| rs2770150 c.-3612 T>C | 0.26 | 0.083 | 0.027 | TT | 277 | 3.24 | 30.38 |
| CT | 204 | 3.31 | 32.84 | ||||
| CC | 34 | 3.09 | 24.97 | ||||
| rs10759931 c.-2604 G>A | 0.42 | 0.906 | 0.656 | GG | 187 | 3.26 | 31.03 |
| GA | 210 | 3.24 | 29.87 | ||||
| AA | 108 | 3.25 | 31.85 | ||||
| rs6478317 c.-2570 A>G | 0.35 | 0.957 | 0.676 | AA | 203 | 3.26 | 31.40 |
| GA | 255 | 3.25 | 30.61 | ||||
| GG | 52 | 3.28 | 31.48 | ||||
| rs10759932 c.-1607 T>C | 0.13 | 0.720 | 0.269 | TT | 365 | 3.25 | 30.71 |
| CT | 115 | 3.30 | 32.15 | ||||
| CC | 5 | 3.19 | 27.80 | ||||
| rs1927911 c.93 + 3211 C>T | 0.25 | 0.630 | 0.491 | CC | 276 | 3.25 | 31.25 |
| CT | 207 | 3.23 | 29.49 | ||||
| TT | 23 | 3.34 | 33.74 | ||||
| rs11536878 c.260 + 546 C>A | 0.12 | 0.620 | 0.649 | CC | 378 | 3.25 | 30.76 |
| CA | 103 | 3.24 | 29.80 | ||||
| AA | 7 | 3.04 | 21.57 | ||||
| rs4986790 Asp299Gly | 0.07 | 0.836 | 0.548 | AA | 441 | 3.25 | 30.86 |
| GA | 68 | 3.26 | 30.60 | ||||
| GG | 3 | 3.45 | 35.33 | ||||
| rs4986791 Thr399Ile | 0.07 | 0.659 | 0.518 | CC | 431 | 3.24 | 30.59 |
| CT | 66 | 3.30 | 33.29 | ||||
| TT | 3 | 3.45 | 35.33 | ||||
| rs11536889 c.3648 + 78 G>C | 0.14 | 0.308 | 0.502 | GG | 373 | 3.27 | 31.66 |
| CG | 128 | 3.19 | 28.44 | ||||
| CC | 8 | 3.36 | 32.63 | ||||
a
SNPs were named according to the Human Genome Variation Society guidelines (http://www.hgvs.org/mutnomen/recs.html).
b
The statistical differences in phenotypes (Ln-transformed PT-IgG titers) were assessed by ANOVA.
c
Distribution of the Pt-IgG titers among the extreme percentiles was tested by Pearson chi-square test.
d
Ln(PT-IgG), Ln-transformed PT-IgG.