TABLE 1.
Method | No. of participants | No. HIV+a | No. BED-CEIA+b | % HIV-1 incidence (95% CI)c |
---|---|---|---|---|
Cross-sectional surveyd | 1,170 | 225 | 34 | 8.2 (5.9-11.5) |
Cohort study (HPTN033 Xinjiang cohort)e | 475 | 42 | 8.8 (6.4-12.0) |
Number of participants whose serum tested positive in an EIA, with confirmation with Western blotting.
Number of participants whose results were categorized as recent infections by BED-CEIA.
95% CI, 95% confidence interval. For the cross-sectional survey, the estimated incidence is a rate, and we applied the natural log scale transformation to compute variances and calculate the 95% CI for the incidence estimate as exp(log[I] ± 1.96/SQRT [Ninc]) (1). For the HPTN033 Xinjiang cohort study, HIV-1 incidence is the cumulative, annualized observed incidence, expressed as the number of new infections per 100 person-years.
A cross-sectional study randomly recruited 1,170 participants concurrently with the HPTN033 Xinjiang Cohort amid the same IDU population; 225 of the 1,170 participants were proved to be HIV positive by the EIA screening test, confirmed by Western blotting.
HIV Prevention Trials Network 033 (HPTN033) is a prospective cohort study. Participating IDUs were enrolled with 6 months of accrual and two semiannual follow-up visits. Participants were screened for seroconversion every 6 months.