TABLE 2.
Geneb | Differential expression in L. monocytogenes parent strain vs ΔhrcA strain
|
Protein function (specific gene name) | |
---|---|---|---|
Adjusted P value | Fold changec | ||
lmo0117 | 0.0003 | −1.8 | LmaB, antigen B (lmaB) |
lmo0124 | 0.0058 | −1.5 | Unknown |
lmo0355 | 0.0013 | −1.6 | Similar to flavocytochrome C fumarate reductase chain A |
lmo0641 | 0.0005 | −1.9 | Similar to heavy metal-transporting ATPase |
lmo0669 | 0.0001 | −2.0 | Similar to oxidoreductase |
lmo0670 | 0.0005 | −1.7 | Unknown |
lmo1257 | 0.0010 | −2.8 | Unknown |
lmo1293 | 0.0003 | −1.9 | Similar to glycerol 3-phosphate dehydrogenase (glpD) |
lmo1407 | 0.0003 | −1.8 | Pyruvate formate lyase-activating enzyme (pflC) |
lmo1474 | 0.0017 | −3.1 | Heat shock protein (grpE) |
lmo1473 | 0.0017 | −4.9 | Heat shock protein (dnaK) |
lmo1472 | 0.0003 | −4.2 | Heat shock protein (dnaJ) |
lmo1471 | 0.0001 | −3.1 | Similar to ribosomal protein L11 methyltransferase |
lmo1470 | 0.0027 | −1.5 | Unknown |
lmo1634 | 0.0071 | −1.9 | Similar to alcohol-acetaldehyde dehydrogenase |
lmo2069 | 0.0003 | −7.0 | Heat shock protein (groES) |
lmo2068 | 0.0003 | −5.4 | Heat shock protein (groEL) |
lmo2070 | 0.0185 | −1.8 | Unknown |
lmo2161 | 0.0006 | −1.5 | Unknown |
lmo2159 | 0.0010 | −1.6 | Similar to oxidoreductase |
lmo2269 | 0.0039 | −1.6 | Unknown |
lmo2460 | 0.0134 | −1.5 | Similar to B. subtilis CggR hypothetical transcriptional regulator |
lmo2459 | 0.0046 | −1.5 | Glyceraldehyde 3-phosphate dehydrogenase (gap) |
lmo2585 | 0.0004 | −1.6 | Similar to B. subtilis YrhD protein |
lmo2637 | 0.0014 | −2.1 | Conserved lipoprotein |
All genes that showed lower transcript levels in the parent strain (i.e., an adjusted P value of <0.05 and n-fold change of ≤−1.5) in the microarray comparison are listed; these genes are either directly or indirectly downregulated by HrcA.
Putative operons are in bold font; gene names correspond to the gene designations for L. monocytogenes strain EGD-e (as listed on the ListiList server http://genolist.pasteur.fr/ListiList/).
A negative n-fold change indicates that the gene has lower transcript levels in the L. monocytogenes parent strain.