FIG. 3.

Aspirin/clopidogrel treatment impairs platelet function but causes neither bleeding nor anemia, and treatment is less efficacious when aspirin or clopidogrel is administered alone. (A) Aggregation of platelets isolated from representative diluent- or aspirin/clopidogrel-treated C57BL/6J mice infected 3 days earlier with RAd35 was measured after arachidonic acid or ADP exposure. Note that while the aggregation of platelets from aspirin/clopidogrel-treated mice was completely abrogated in response to arachidonic acid, the aggregation in response to ADP resulted, as expected, in the formation of aggregates that were smaller and unstable (i.e., they rapidly disaggregated). (B) Hematocrit values (means ± standard deviations; n = 8) were assessed individually 3 days after the indicated treatment. (C) sALT (units/liter) measured 3 days after the indicated treatment is expressed as means ± standard deviations; n = 8.