TABLE 2.
Domain | Activated aa | Signature aa at position:
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|
235 | 236 | 239 | 278 | 299 | 301 | 322 | 330 | 331 | ||
A1 | Aib | D | L | G | Y | L | A | G | V | F |
A2 | Pro | D | I | L | I | C | A | L | I | C |
v | f | g | ||||||||
A3 | Aib | D | V | G | F | L | A | G | V | F |
l | ||||||||||
A4 | Ala | D | L | G | F | L | A | G | V | F |
v | v | l | ||||||||
A4 | Aib | D | M | G | F | I | A | G | V | V |
l | l | f | ||||||||
A5 | Gln | D | G | G | M | V | G | G | N | Y |
A6 | Aib | D | L | G | Y | V | A | G | V | F |
A7 | Val | D | A | F | L | L | G | I | V | A |
i | g | l | ||||||||
A8 | Aib | D | L | G | Y | L | A | G | C | F |
v | ||||||||||
A9 | Gly | D | V | G | Y | L | M | A | V | L |
i | f | |||||||||
A10 | Leu | D | F | S | Y | L | G | A | V | M |
l | f | g | v | |||||||
A11 | Aib | D | L | G | F | L | A | G | V | F |
A12 | Pro | D | V | L | F | C | G | L | I | C |
A13 | Val | D | A | A | L | V | V | G | V | F |
g | m | i | i | |||||||
A14 | Aib | D | L | G | F | L | A | G | V | F |
A15 | Aib/Iva | D | M | G | W | M | G | G | V | I |
f | a | v | ||||||||
A16 | Gln | D | G | G | M | V | G | G | N | Y |
A17 | Gln | D | G | G | M | I | G | G | N | Y |
v | ||||||||||
A18 | Phe | D | A | A | I | L | V | G | V | G |
f | l | m |
Challis et al. (7). Identical signature amino acids are underlined. If the corresponding signature amino acid is different in PAR1, the respective amino acid is indicated by a lowercase letter below that of PBS1. Since no activation domain for leucine (A10) is present in PAR1, its signature was taken from TEX1, and identical amino acids are indicated in boldface to illustrate this difference. aa, amino acids.