TABLE 2.

Signature sequences of the A domains of H. atroviridis PBS1 compared to H. jecorina PAR1^a

Domain	Activated aa	Signature aa at position:
		235	236	239	278	299	301	322	330	331
A1	Aib	D	L	G	Y	L	A	G	V	F
A2	Pro	D	I	L	I	C	A	L	I	C
			v		f		g
A3	Aib	D	V	G	F	L	A	G	V	F
			l
A4	Ala	D	L	G	F	L	A	G	V	F
			v			v				l
A4	Aib	D	M	G	F	I	A	G	V	V
			l			l				f
A5	Gln	D	G	G	M	V	G	G	N	Y
A6	Aib	D	L	G	Y	V	A	G	V	F
A7	Val	D	A	F	L	L	G	I	V	A
						i		g		l
A8	Aib	D	L	G	Y	L	A	G	C	F
									v
A9	Gly	D	V	G	Y	L	M	A	V	L
							i			f
A10	Leu	D	F	S	Y	L	G	A	V	M
				l		f		g		v
A11	Aib	D	L	G	F	L	A	G	V	F
A12	Pro	D	V	L	F	C	G	L	I	C
A13	Val	D	A	A	L	V	V	G	V	F
				g	m	i	i
A14	Aib	D	L	G	F	L	A	G	V	F
A15	Aib/Iva	D	M	G	W	M	G	G	V	I
						f	a			v
A16	Gln	D	G	G	M	V	G	G	N	Y
A17	Gln	D	G	G	M	I	G	G	N	Y
						v
A18	Phe	D	A	A	I	L	V	G	V	G
					f	l	m

^aChallis et al. (7). Identical signature amino acids are underlined. If the corresponding signature amino acid is different in PAR1, the respective amino acid is indicated by a lowercase letter below that of PBS1. Since no activation domain for leucine (A10) is present in PAR1, its signature was taken from TEX1, and identical amino acids are indicated in boldface to illustrate this difference. aa, amino acids.