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. 2007 Jul 30;75(11):5434–5442. doi: 10.1128/IAI.00411-07

FIG. 3.

FIG. 3.

Bactericidal activity against N. meningitidis strains of serum antibodies from mice immunized with OMV vaccines. Sera from 20 mice (see Table 4) were pooled, and two to four pools were combined. Bactericidal assays with (A) H44/76 and (B) Cu385 were performed using pooled sera from mice immunized with OMVs from either TbpA-, Hsf-, or Tbp/Hsf-overproducing strains or with a 1:1 (vol/vol) mixture of serum pools from mice immunized with OMVs from TbpA- and Hsf-overproducing strains. Bactericidal activity is expressed as the reciprocal antibody titer. (C) Bactericidal assays with strain M97-250687 were performed using pooled sera from mice immunized with OMVs from either Omp85-, NspA-, or TbpA/Hsf-overproducing strains or a combination thereof. The data are the means of three different mixing experiments performed using the same serum samples and are expressed as the reciprocal bactericidal titers.