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T. denticola utilizes TLR2 and not TLR4 to activate NF-κB. HEK293 cells expressing TLR2 or TLR4 were stimulated with various MOIs of T. denticola for 24 h and then analyzed for activation of NF-κB by the secreted alkaline phosphatase assay. An asterisk indicates statistical significance with a P value of <0.05 compared to results for parental HEK293 cells. The data represent the arithmetic means ± standard deviations for five separate experiments.
