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T. denticola requires TLR2 for the activation of innate immune responses. Peritoneal macrophages obtained from wild-type (wt), TLR2-deficient (TLR2-ko), or TLR4-deficient (TLR4-ko) mice were stimulated with T. denticola and assessed for TNF-α production 20 h poststimulation. The asterisk indicates statistical significance at P values of <0.05 compared to results for wild-type cells. The data represent the arithmetic means ± standard deviations for three separate experiments.
