FIG. 3.

Assessment of which TLR2 (TLR2/1 or TLR2/6) coreceptor complex is utilized by T. denticola demonstrates that TLR6 but not TLR1 is involved in mediating cellular responses. TLR6 knockout macrophages produced significantly (P < 0.05) less TNF-α than wild-type macrophages stimulated with T. denticola. An asterisk indicates statistical significance at P values of <0.05 compared to results for wild-type cells. The data represent the arithmetic means ± standard deviations for three separate experiments.