TABLE 3.

P. berghei challenge of vaccinated mice depleted of CD4⁺ and CD8⁺ T cells^a

Immunization	No. protected/no. challenged	Protection (%)
F+C/M+C	15/18	83
F+C/M+C CD4−	5/6	83
F+C/M+C CD8−	8/18	44
Naive	0/18	0

^aBALB/c mice were immunized with the F+C/M+C regimen with a 2-week interval between prime and boost. Two groups of F+C/M+C-immunized animals were depleted of CD8⁺ (F+C/M+C CD8⁻) or CD4⁺ (F+C/M+C CD4⁻) T cells on days 10 and 13 postboost. Mice were challenged i.v. with 1,000 live P. berghei sporozoites 14 days after boosting and monitored 5 to 14 days postchallenge by Giemsa-stained blood film. Animals were considered protected if no parasites were detected in this time. Results are from two pooled experiments, except for the CD4-depleted group.