TABLE 3.
Survival of mice immunized with PspA fragments and hybrids after a challenge with pneumococcal strains containing PspA fragments from different families and clades
| Groupd | No. of mice alive/total (P value)
|
||
|---|---|---|---|
| Strain A66.1 (PspA1 and -2, serotype 3)a | Strain St 679/99 (PspA3, serotype 6B)b | Strain 3JYP2670 (PspA4, serotype 3)a | |
| Alum | 0/6 | 0/6 | 0/12 |
| PspA1ABC | 4/6 (0.03)c | 2/6 (0.2) | 1/12 (>0.2) |
| PspA3ABC | 3/5 (0.06) | 5/6 (0.007)c | 0/12 |
| PspA1ABC-4B | 4/6 (0.03)c | 2/6 (0.2) | 5/12 (0.02)c |
| PspA1ABC-3AB | 6/6 (0.001)c | 4/6 (0.03)c | 2/12 (0.2) |
a
Intravenous challenge.
b
Intraperitoneal challenge.
c
Survival rates were significantly different from those of controls (P < 0.05, Fisher's exact test). Survival was measured 10 days after a challenge.
d
Strains are listed with their PspA clades and capsular types.