FIG. 5.
Effect of depletion of CD8+ T cells or plasmacytoid dendritic cells on bacterial burdens in the lung following i.n. inoculation with A. baumannii. Groups of five C57BL/6 mice were treated by i.p. injection with either 500 μg of MAb TIB210 (top), 150 μg of MAb 120G8 (bottom), or an equivalent amount of control rIgG at 18 h before i.n. challenge with 2.5 × 107 CFU of A. baumannii. Bacterial burdens in the lung were determined by quantitative bacteriology. The data are presented as mean ± SD (n = 5), and the detection limit for the bacterial burdens was 1.3 log10 CFU/lung.