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. 2007 Oct 1;75(12):5597–5608. doi: 10.1128/IAI.00762-07

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Copyright © 2007, American Society for Microbiology

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FIG. 9. — Effect of RB6 treatment on cytokine and chemokine levels in sera (A) and BAL fluid (B) from mice i.n. inoculated with A. baumannii. Groups of five C57BL/6 mice were treated by i.p. injection with either 250 μg of RB6 (open bars) or an equivalent amount of control rIgG (solid bars) at −18 and +24 h after i.n. challenge with 10⁷ CFU of A. baumannii. Blood and BAL samples were collected at 0, 4, 24, and 72 h. Cytokine and chemokine levels in the serum and BAL fluid were determined using the mouse panel of Fluorokine MAP Multiplex Kits (R & D Systems, Inc., Minneapolis, MN) on a Luminex 100 IS instrument. Data are expressed as mean ± SD for five mice at each time point. The detection limits of the assays were 2.5 to 15 pg/ml, as indicated by dotted lines. *, P < 0.05; **, P < 0.01; ***, P < 0.005 (versus control rIgG-treated mice).

FIG. 9. — Effect of RB6 treatment on cytokine and chemokine levels in sera (A) and BAL fluid (B) from mice i.n. inoculated with A. baumannii. Groups of five C57BL/6 mice were treated by i.p. injection with either 250 μg of RB6 (open bars) or an equivalent amount of control rIgG (solid bars) at −18 and +24 h after i.n. challenge with 10⁷ CFU of A. baumannii. Blood and BAL samples were collected at 0, 4, 24, and 72 h. Cytokine and chemokine levels in the serum and BAL fluid were determined using the mouse panel of Fluorokine MAP Multiplex Kits (R & D Systems, Inc., Minneapolis, MN) on a Luminex 100 IS instrument. Data are expressed as mean ± SD for five mice at each time point. The detection limits of the assays were 2.5 to 15 pg/ml, as indicated by dotted lines. *, P < 0.05; **, P < 0.01; ***, P < 0.005 (versus control rIgG-treated mice).