TABLE 3.
Oxidative stress response and TLR4 signaling pathway transcripts in infected versus uninfected skin from both groups of volunteers
| Category and gene symbol | Protein | Change in transcript levela in group:
|
|
|---|---|---|---|
| RR | PP | ||
| Oxidative stress response | |||
| CATb | Catalase | — | −2.9 |
| CREB1 | CAMP-responsive element binding protein 1 | 1.7 | 2.2 |
| GPX2 | Glutathione peroxidase 2 | 1.7 | — |
| GSTA1 | Glutathione S-transferase A1 | — | −1.7 |
| GSTA4 | Glutathione S-transferase A4 | −1.9 | −2.7 |
| GSTK1 | Glutathione S-transferase kappa 1 | 2.3 | 1.6 |
| GSTM1b | Glutathione S-transferase M1 | −2.4 | −2.5 |
| GSTM2 | Glutathione S-transferase M2 | −2.4 | −2.7 |
| GSTM3 | Glutathione S-transferase M3 | — | −3.3 |
| GSTM4 | Glutathione S-transferase M4 | — | −2.0 |
| GSTM5 | Glutathione S-transferase M5 | −5.1 | −5.8 |
| GSTO1b | Glutathione S-transferase omega 1 | 3.0 | 2.4 |
| GSTO2 | Glutathione S-transferase omega 2 | −1.8 | −2.0 |
| GSTT1 | Glutathione S-transferase theta 1 | — | −3.0 |
| MGST1b | Microsomal glutathione S-transferase 1 | — | −3.1 |
| MGST3 | Microsomal glutathione S-transferase 3 | — | −2.1 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | — | −6.1 |
| TLR4 signaling pathways | |||
| IRAK2 | IL-1 receptor-associated kinase 2 | 3.1 | — |
| IRF3 | IFN regulatory factor 3 | — | 2.1 |
| MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | −2.1 | — |
| MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | — | 2.2 |
| MAP3K7IP3 | Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 | — | 2.6 |
| MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | — | 2.4 |
| MAPK14 | Mitogen-activated protein kinase 14 | −2.0 | — |
| MAPK10 | Mitogen-activated protein kinase 10 | — | −2.4 |
| MAPKAP1 | Mitogen-activated protein kinase-associated protein 1 | — | 1.4 |
| MAPKAPK2 | Mitogen-activated protein kinase-activated protein kinase 2 | — | 1.6 |
| MYD88 | Myeloid differentiation primary response gene 88 | 3.5 | 4.9 |
| TBK1 | TANK-binding kinase 1 | — | 2.1 |
| TICAM2b | TLR adaptor molecule 2 | 2.4 | — |
a
Values are fold changes in transcript levels between infected and uninfected tissue (P < 0.05). —, not significantly different between infected and uninfected tissue.
b
Transcript detected by multiple probe sets; values shown are from the probe set that had the largest fold change for one of the groups.