TABLE 3.
Category and gene symbol | Protein | Change in transcript levela in group:
|
|
---|---|---|---|
RR | PP | ||
Oxidative stress response | |||
CATb | Catalase | — | −2.9 |
CREB1 | CAMP-responsive element binding protein 1 | 1.7 | 2.2 |
GPX2 | Glutathione peroxidase 2 | 1.7 | — |
GSTA1 | Glutathione S-transferase A1 | — | −1.7 |
GSTA4 | Glutathione S-transferase A4 | −1.9 | −2.7 |
GSTK1 | Glutathione S-transferase kappa 1 | 2.3 | 1.6 |
GSTM1b | Glutathione S-transferase M1 | −2.4 | −2.5 |
GSTM2 | Glutathione S-transferase M2 | −2.4 | −2.7 |
GSTM3 | Glutathione S-transferase M3 | — | −3.3 |
GSTM4 | Glutathione S-transferase M4 | — | −2.0 |
GSTM5 | Glutathione S-transferase M5 | −5.1 | −5.8 |
GSTO1b | Glutathione S-transferase omega 1 | 3.0 | 2.4 |
GSTO2 | Glutathione S-transferase omega 2 | −1.8 | −2.0 |
GSTT1 | Glutathione S-transferase theta 1 | — | −3.0 |
MGST1b | Microsomal glutathione S-transferase 1 | — | −3.1 |
MGST3 | Microsomal glutathione S-transferase 3 | — | −2.1 |
NQO1 | NAD(P)H dehydrogenase, quinone 1 | — | −6.1 |
TLR4 signaling pathways | |||
IRAK2 | IL-1 receptor-associated kinase 2 | 3.1 | — |
IRF3 | IFN regulatory factor 3 | — | 2.1 |
MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | −2.1 | — |
MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | — | 2.2 |
MAP3K7IP3 | Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 | — | 2.6 |
MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | — | 2.4 |
MAPK14 | Mitogen-activated protein kinase 14 | −2.0 | — |
MAPK10 | Mitogen-activated protein kinase 10 | — | −2.4 |
MAPKAP1 | Mitogen-activated protein kinase-associated protein 1 | — | 1.4 |
MAPKAPK2 | Mitogen-activated protein kinase-activated protein kinase 2 | — | 1.6 |
MYD88 | Myeloid differentiation primary response gene 88 | 3.5 | 4.9 |
TBK1 | TANK-binding kinase 1 | — | 2.1 |
TICAM2b | TLR adaptor molecule 2 | 2.4 | — |
Values are fold changes in transcript levels between infected and uninfected tissue (P < 0.05). —, not significantly different between infected and uninfected tissue.
Transcript detected by multiple probe sets; values shown are from the probe set that had the largest fold change for one of the groups.