TABLE 4.
Selected transcripts that were differentially regulated in infected versus uninfected DC derived from both groups of volunteers
| Category and gene symbol | Protein | Change in transcript levela in group:
|
|
|---|---|---|---|
| RR | PP | ||
| DC1 | |||
| CD44b | CD44 antigen (homing function; Indian blood group) | 3.1 | 5.5 |
| CSF3 | Colony-stimulating factor 3 (G-CSF) | 38.0 | 56.6 |
| IL1A | IL-1, alpha | 53.0 | 93.4 |
| IL1Bb | IL-1, beta | 73.9 | 59.2 |
| IL2RA | IL-2 receptor, alpha | 15.8 | 49.4 |
| IL6 | IL-6 (IFN, beta 2) | 247.9 | 692.4 |
| IL8 | IL-8 | 54.5 | 163.6 |
| IL10RA | IL-10 receptor, alpha | 2.2 | 2.3 |
| IL12B | IL-12B (IL-12p40) | 57.0 | 274.8 |
| IL15 | IL-15 | 7.9 | 35.2 |
| JAG1 | Jagged 1 (Alagille syndrome) | 6.4 | 4.0 |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 | 411.2 | 1,021.5 |
| TNFα | TNF (TNF superfamily, member 2) | 14.4 | 51.0 |
| IFN or TNF induced | |||
| GBP1b | Guanylate binding protein 1, IFN inducible, 67 kDa | 17.3 | 28.0 |
| GBP2 | Guanylate binding protein 2, IFN inducible | 9.0 | 20.9 |
| ISG20 | IFN-stimulated gene product, 20 kDa | 30.0 | 372.0 |
| TNFαIP2 | TNF-α-induced protein 2 | 3.6 | 6.4 |
| TNFαIP3b | TNF-α-induced protein 3 | 6.6 | 6.2 |
| TNFαIP6 | TNF-α-induced protein 6 | 51.4 | 98.7 |
| DC maturation | |||
| CD1C | CD1C antigen, c polypeptide | −4.0 | −3.4 |
| CD80 | CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) | 20.1 | 44.9 |
| ICAM-1b | Intercellular adhesion molecule 1 (CD54) | 11.0 | 14.3 |
| DCreg | |||
| PDCD1LG1b | Programmed cell death 1 ligand 1 | 4.2 | 8.4 |
| Signal transduction | |||
| NFKB1 | NF-κB (p105) | 4.4 | 5.0 |
| STAT3 | Signal transducer and activator of transcription 3 | 3.6 | 5.6 |
| TLR/NLRc pathways | |||
| CARD15 | Caspase recruitment domain family, member 15 (NOD2) | 11.8 | 10.5 |
| IRAK3 | IL-1 receptor-associated kinase | 3.6 | 6.7 |
| TLR4b | TLR4 | −2.6 | −3.3 |
| TRAF1b | TNF receptor-associated factor 1 | 8.3 | 9.5 |
a
Values are fold changes in transcript levels between infected and uninfected tissue (P < 0.05).
b
Transcript detected by multiple probe sets; values shown are from the probe set that had the largest fold change for one of the groups.
c
NLR, NOD-like receptor.