TABLE 5.
Category and gene symbol | Protein | Change in transcript levela in group:
|
|
---|---|---|---|
RR | PP | ||
DC1 or DC maturation | |||
CD38 | CD38 antigen (p45) | — | 73.3 |
CCR7 | Chemokine (C-C motif) receptor 7 | — | 17.1 |
CD58b | CD58 antigen (lymphocyte function-associated antigen 3) | — | 2.9 |
LAMP3 | Lysosome-associated membrane protein 3 | — | 14.2 |
GM-CSF | Colony-stimulating factor 2 (GM-CSF) | — | 50.4 |
IL1F9 | IL-1 family, member 9 | 3.3 | — |
IL7 | IL-7 | — | 2.2 |
IL16 | IL-16 (lymphocyte chemoattractant factor) | — | −4.3 |
IL18 | IL-18 (IFN-γ-inducing factor) | — | 14.6 |
CASP1b | Caspase 1 (apoptosis-related cysteine protease) | — | 8.9 |
IL23α | IL-23, alpha subunit p19 | 3.0 | — |
IRF4 | IFN regulatory factor 4 | 2.5 | — |
IRF1 | IFN regulatory factor 1 | 6.8 | — |
Immunomodulatory | |||
SOCS2 | Suppressor of cytokine signaling 2 | — | 5.5 |
SOCS3 | Suppressor of cytokine signaling 3 | — | 30.0 |
Signal transduction | |||
STAT4 | Signal transducer and activator of transcription 4 | — | 23.5 |
STAT1 | Signal transducer and activator of transcription 1 | 2.0 | — |
Inhibition of maturation | |||
LILRB1b | Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | −2.0 | — |
DCreg | |||
CD200 | CD200 antigen | — | 38.8 |
CD84 | CD84 antigen (leukocyte antigen) | — | −3.0 |
INDO | Indoleamine-pyrrole 2,3-dioxygenase | — | 173.2 |
IL10 | IL-10 | — | 7.4 |
NOTCH2NL | Notch homolog 2 (Drosophila), N-terminal like | — | 2.5 |
Proinflammatory | |||
MIF | Macrophage MIF | 2.0 | — |
TLR pathways | |||
IRAK1BP1 | IL-1 receptor-associated kinase 1 binding protein 1 | — | 2.6 |
TBK1 | Tank-binding kinase 1 | — | 2.0 |
TLR1 | TLR1 | — | 3.5 |
TRIF | TIR domain containing adaptor inducing IFN-β | — | 2.0 |
IFN responsive | |||
G1P3 | IFN, alpha-inducible protein (clone IFI-6-16) | — | 6.6 |
IFI44 | IFN-induced protein 44 | — | 9.3 |
IFIH1 | IFN induced with helicase C domain 1 | — | 3.3 |
IFIT5 | IFN-induced protein with tetratricopeptide repeats 5 | — | 2.8 |
IFITM1b | IFN-induced transmembrane protein 1 (9-27) | — | 18.4 |
IFITM2 | IFN-induced transmembrane protein 2 (1-8D) | — | 7.0 |
IFITM3 | IFN-induced transmembrane protein 3 (1-8U) | — | 10.0 |
IFI44L | IFN-induced protein 44 | 9.1 | — |
MNDA | Myeloid cell nuclear differentiation antigen | −2.5 | — |
Antigen presentation | |||
CD1D | CD1D antigen, d polypeptide | — | −13.1 |
HLA-B | MHC, class I, B | — | 2.7 |
HLA-DQα1 | MHC, class II, DQ alpha 1 | — | 3.0 |
HLA-DMα | MHC, class II, DM alpha | — | −3.1 |
HLA-DMβ | MHC, class II, DM beta | — | −11.2 |
HLA-F | MHC, class I, F | — | 3.1 |
HM13 | Histocompatibility (minor) 13 | — | −2.1 |
Values are fold changes in transcript levels between infected and uninfected tissue (P < 0.05). —, not significantly different between infected and uninfected tissue.
Transcript detected by multiple probe sets; values shown are from the probe set that had the largest fold change for one of the groups.