FIG. 5.
SUN41 requirement for tissue infiltration during disseminated and oropharyngeal candidiasis. (A to F) Mice were infected as described in the Fig. 3 legend, and kidneys were harvested after day 1 (A to C) and day 4 (D to F) of infection. Thin sections of the kidneys were stained with periodic acid-Schiff stain. Arrows in panels B and E point to a rare infiltration by the sun41Δ/sun41Δ mutant. (G to I) Three groups of seven mice were immunosuppressed with cortisone acetate and orally inoculated with swabs saturated in 106 vegetative cells per ml of DAY185, sun41Δ/sun41Δ, or sun41Δ/sun41Δ+pSUN41 cells for 75 min. Tongues were excised after 5 days of infection, and thin sections were stained with periodic acid-Schiff stain. All sections in these panels were visualized at ×40 and are presented at the same magnification. Bars (A and G), 30 μM.