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Expression of hph results in lethality among mice infected with Histoplasma capsulatum. Groups of mice were infected intranasally with 2 × 104 to 2 × 107 yeast cells of H. capsulatum strain G217B (n = 8), strain G186AR (n = 8), the hygromycin-resistant G217B derivative UC1 (n = 16), or the hygromycin-resistant G186AR derivative UC2 (n = 8). Survival curves demonstrate the loss of animals infected with >2 × 105 hygromycin-resistant H. capsulatum cells between days 9 and 20.
