TABLE 3.
Organism or type | MIC (mg/liter)
|
|||||||
---|---|---|---|---|---|---|---|---|
Amphotericin B
|
Itraconazole
|
Voriconazole
|
Posaconazole
|
|||||
MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | |
E. phaeomuriformis | 0.5 | 1 | ≤0.015 | 0.03 | 0.03 | 0.06 | ≤0.015 | ≤0.015 |
E. xenobiotica | 0.25 | 0.5 | 0.03 | 0.125 | 0.125 | 0.5 | ≤0.015 | 0.03 |
E. bergeri | 0.25 | 0.25 | 0.125 | 0.25 | 1.0 | 1.0 | 0.03 | 0.03 |
E. lecanii-corni | 0.25 | 0.5 | 0.06 | 0.125 | 0.06 | 0.5 | ≤0.015 | 0.03 |
E. spinifera | 0.5 | 0.5 | 0.03 | 0.06 | 0.125 | 0.5 | ≤0.015 | 0.03 |
E. jeanselmei | 0.5 | 1 | 0.03 | 0.06 | 0.125 | 0.25 | ≤0.015 | 0.03 |
E. mesophila | 0.25 | 0.5 | 0.125 | 0.25 | 0.5 | 0.25 | 0.06 | 0.06 |
E. dermatitidis | 0.5 | 1.0 | 0.125 | 0.25 | 0.125 | 0.25 | 0.03 | 0.06 |
E. oligosperma | 0.25 | 0.5 | 0.06 | 0.125 | 0.25 | 1.0 | 0.03 | 0.03 |
Susceptibleb | ≤1.0 | ≤0.5 | ≤2.0 | ? | ||||
Resistantc | >2.0 | ≥1.0 | >2.0 | ? |
No defined breakpoints are available for the genus Exophiala, and the clinical correlates are primarily anecdotal. AMB, amphotericin B, ITRA.
Suggested MIC for clinical efficacy based upon in vitro data.
Suggested MIC for less than favorable clinical outcome based upon in vitro data.