TABLE 2.

Occurrence and frequency of the various drug resistance mutations (per codon) by sequence analysis and LiPA

Assay	Mutation(s) at codon:						Frequency (no. of mutants)
	80	173	180	181	204	236	Baseline	Wk 12	Wk 24	Wk 52	Wk 156
Sequencing					M204I				1	1	1
			L180M		M204I						1
			L180M		M204I, M204V						2
	L80I				M204I		1		3	7	1
	L80I		L180M		M204I						1
	L80I		L180M		M204I, M204V						2
	L80I	V173L			M204I						1
	L80V				M204I					1
	L80V		L180M		M204I						1
	L80I		L180M		M204V					1
		V173L	L180M		M204V						1
	L80I									1
				A181T				1	2	1
						N236T		1
Total							1	2	6	12	11
LiPA					M204I			3	3	3
			L180M		M204I
			L180M		M204I, M204V						1
	L80I				M204I			1	2	3	1
	L80I		L180M		M204I						1
	L80I		L180M		M204I, M204V					1
	L80I	V173L			M204I						1
	L80V				M204I
	L80V		L180M		M204I
	L80I		L180M		M204V
		V173L	L180M		M204V
	L80I
				A181T				3	5	4	2
						N236T				1
	L80I				M204I, M204V					1
	L80I, L80V				M204I		1		1	1
	L80I, L80V			A181T	M204I, M204V	N236T	1
	L80I, L80V		L180M		M204I, M204V	N236T			1	1	1
			L180M	A181T	M204I	N236T			1
				A181T	M204I			1		3
	L80V		L180M	A181T	M204V						1
	L80V			A181T					2
	L80V				M204I, M204V						1
	L80V		L180M		M204I, M204V					1	1
					M204I, M204V				1	1
		V173L	L180M		M204I, M204V						1
	L80I	V173L	L180M		M204V						1
					M204V		1	1		2
	L80I				M204I	N236T			1
			L180M		M204V					1
	L80I, L80V		L180M		M204I, M204V					1	1
	L80I			A181T	M204I, M204V			1
	L80I, L80V		L180M		M204I					1
	L80I		L180M	A181T	M204I						1
Total							3	10	17	25	14