TABLE 2.
Patient no. | Sample type | Patient
|
Days between onset and collection | Diagnosis | Symptom(s) | CSF information
|
HHV-6 real-time PCR CT value | HHV-6 typing result | Typing primer used | Other agents detected | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sex | Age (yr) | CSF abnormality | Protein level (mg/dl) | WBC count | % Lymphs | |||||||||
1 | CSF | M | 12 | 10 | Encephalitis | Fever, altered mental status, hallucinations | Yes | 56 | 35 | 95 | 31.78 | B | U86 | |
2 | CSF | F | 12 | 2 | Encephalitis | Fever, altered mental status | No | 33 | 4 | Unknown | 31.98 | B | U86 | |
3 | CSF | F | 2 | 7 | Encephalitis | Fever, altered mental status, seizures, muscle weakness | Unknown | Unknown | Unknown | Unknown | 36.07 | Untyped | U86 | |
4 | CSF | M | 45 | Unknown | Encephalitis | Fever, headache, seizures, altered mental status, muscle weakness, muscle pain | Yes | Unknown | 20 | 80 | 34.3 | Untyped | U86 | |
5 | CSF | M | 2 | 1 | Encephalitis | Fever, seizures, altered mental status | No | 16 | 0 | Unknown | 39.3 | B | U95 | |
6 | CSF | F | 1 | 0 | Unknown | Fever, rash, altered mental status, increased AST/ALT | Yes | 483 | 2 | 50 | 38.65 | Untyped | U86 | |
7 | CSF | M | 2 | 0 | Meningitis | Fever, altered mental status, cough | Unknown | 28 | Unknown | Unknown | 36.5 | B | U86 | |
8 | CSF | F | 30 | 31 | Encephalitis; acute onset psychosis | Headache, rash, altered mental status, confusion, hyperactivity | Yes | 13 | 10 | 100 | 32.29 | B | U95 | |
9 | CSF | M | 8 | Unknown | Encephalitis | Seizures, altered mental status, muscle weakness, stiff neck | Yes | 35 | 58 | 90 | 37.58 | B | U95 | |
10 | CSF | M | 38 | 14 | Encephalitis | Fever, altered mental status, headache, stiff neck | Yes | Unknown | Unknown | Unknown | 39.74 | Untyped | U95 | EBV+ve |
11 | CSF | F | 1 | Unknown | Encephalitis | Seizures | Unknown | Unknown | Unknown | Unknown | 33.3 | B | U95 | |
12 | CSF/autopsy | M | 2 | Unknown | Encephalitis; meningitis | Seizures | Unknown | Unknown | Unknown | Unknown | 38.47 | B | U95 | |
13 | CSF | M | 17 | 1 | Meningitis | Headache, stiff neck, muscle weakness, muscle pain | Yes | 150 | 40 | 29 | 25.03 | B | U95 | |
14 | CSF | F | 81 | 5 | Encephalitis | Fever, headache, rash, altered mental status | Unknown | Unknown | Unknown | Unknown | 33.56 | Untyped | U95 | |
15 | CSF | F | 4 | 0 | Encephalitis | Fever, seizures, altered mental status | No | 25 | 2 | 0 | 34.75 | B | U95 | |
16 | CSF | F | 8 | 3 | Meningitis | Fever, headache, stiff neck, meningeal sign | Yes | 66 | 228 | 58 | 39.92 | B | U95 | |
17 | Liver tissue | F | 30 | 7 | Unknown | Fever, rash, elevated LFT result, jaundice, pruritis | N/A | N/A | N/A | N/A | 34 | B | U95 | |
18 | CSF | M | 60 | 1 | Meningoencephalitis | Fever, seizures, altered mental status | Yes | 49 | 99 | N/A | 28.89 | B | U95 | |
19 | CSF | M | 25 | 1 | Meningitis | Muscle weakness | Yes | 119 | 49 | 100 | 28.68 | B | U95 | |
20 | CSF/autopsy | F | 1 | Unknown | Unknown | Sickle cell disease, anemia, fever | Unknown | Unknown | Unknown | Unknown | 37.96 | B | U95 | Adv+ve |
21 | CSF/autopsy | M | 2 | Unknown | Unknown | Fever, cough, bronchiolitis symptoms | Unknown | Unknown | Unknown | Unknown | 37.35 | B | U95 | |
22 | CSF | M | 71 | 8 | Encephalitis | Fever, altered mental status | Yes | 117 | 47 | 100 | 29.62 | Untyped | U95 | EBV+ve |
23A | CSF | F | 3 | 16 | Encephalitis; cerebellitis | Muscle weakness, ataxia | Unknown | Unknown | Unknown | Unknown | 32.2 | B | U95 | |
23B | Serum | 27 | Unknown | N/A | N/A | N/A | N/A | 30.7 | B | U95 | ||||
23C | CSF | 34 | Headache, altered mental status, vomiting, tremor | No | 15 | 1 | Unknown | 36.09 | B | U95 | ||||
24 | CSF | M | 1 | 2 | Encephalitis | Fever, muscle weakness, altered mental status, seizures, rash | Yes | 288 | 5 | 65 | 32.9 | B | U95 |
F, female; M, male; AST/ALT, alanine aminotransferase/aspartate aminotransferase; LFT, liver function test; % Lymphs, number of lymphocytes as a percentage of total WBC count; N/A, not applicable; Adv, adenovirus. U86 and U95 are the genes targeted in the HHV-6 PCR typing assays. Three specimens were tested for patient 23 (A, B, and C).