TABLE 5.

Baseline and week-24 parameters which are predictive of undetectable serum HBV DNA at week 48 of therapy

Parameter	Value	Proportion (%) of patients with undetectable serum HBV DNA	P value
Baseline HBcrAg	<40,000 vs ≥40,000 kU/ml	29/31 (94) vs 2/8 (25)	<0.001
Baseline intrahepatic total HBV DNA	<100 vs ≥100 copies/cell	27/29 (93) vs 2/8 (25)	< 0.001
Baseline cccDNA	<5 vs ≥5 copies/cell	27/29 (93) vs 2/8 (25)	< 0.001
Baseline cytoplasmic HBcAg staining	≤25% vs >25%	28/32 (88) vs 2/6 (33)	0.012
Baseline nuclear HBcAg staining	≤25% vs >25%	30/35 (86) vs 0/3 (0)	0.007
Wk-24 HBcrAg	<200 vs ≥200 kU/ml	22/23 (96) vs 9/16 (56)	0.004