Figure 5.

Possible explanations of PGKB toxicity. The pathway of glucose metabolism in wild-type bloodstream trypanosomes is shown; the additional steps that may be involved in toxicity are in the shaded area on the right. Hypothetical pathways or steps are indicated with broken lines; a hypothetical cytosolic triose-phosphate isomerase is shown as (TIM) in right part of figure. GLC, glucose; FBP, fructose bisphosphate; DHAP, dihydroxyacetone phosphate; G3P, glycerol-3-phosphate; GAP, glyceraldehyde-3-phosphate; BPG, bisphosphoglycerate; 3PG, 3-phosphoglycerate; 2PG, 2-phosphoglycerate; PEP, phosphoenolpyruvate; PYR, pyruvate; TIM, triose-phosphate isomerase; GPDH, glycerol 3-phosphate dehydrogenase; MOX, mitochondrial oxidase; cGAPDH, glyceraldehyde 3-phosphate dehydrogenase, cytosolic isozyme; gGAPDH, glyceraldehyde-3-phosphate dehydrogenase, glycosomal isozyme; gPGK, phosphoglycerate kinase, glycosomal isozyme; cPGK, phosphoglycerate kinase, cytosolic isozyme; PGM, phosphoglucomutase; ENO, enolase; PYK, pyruvate kinase.