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. 2007 Oct 5;189(24):8922–8927. doi: 10.1128/JB.00925-07

FIG. 1.

FIG. 1.

MEP pathway. The reaction catalyzed by CDP-ME synthase (IspD) is highlighted. In M. tuberculosis, IPP and DMAPP are synthesized through the activities of a cascade of enzymes (DXS through IspH). DXS, 1-deoxy-d-xylulose 5-phosphate synthase; IspC, 1-deoxy-d-xylulose 5-phosphate reductoisomerase; IspD, 4-diphosphocytidyl-2-C-methyl-d-erythritol synthase; IspE, 4-diphosphocytidyl-2-C-methyl-d-erythritol kinase; IspF, 2-C-methyl-d-erythritol 2,4-cyclodiphosphate synthase; IspG, 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; IspH, 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase. Identification numbers have been included for M. tuberculosis enzymes for which there is experimental evidence of activity.