TABLE 1.
Change in expression of staphylococcal extracellular accessory protein and regulatory genes in a nonhemolytic variant
| Gene | Virulence factor | Fold changea |
|---|---|---|
| agrACDB | Accessory gene regulator | −9 |
| cap5a | Polysaccharide capsule type 5 | −6 |
| clfB | Clumping factor B | 4 |
| geh | Glycerol ester hydrolase | −3 |
| hlb | Beta-hemolysin | −18 |
| hld/RNAIII | Delta-hemolysin/toxin | −33 |
| hlgBC | Gamma-hemolysin (components B and C) | −11 |
| lip | Butyryl lipase | −8 |
| lukS/F | P-V leukocidin | −6 |
| plc | Phosphatidylinositol-specific phospholipase C | −10 |
| sak | Staphylokinase | −4 |
| sarU | SarU (SarA homolog) | −6 |
| scp | Staphopain | −8 |
| splA-F | Serine protease-like | −41 |
| sspA | Serine protease (V8 protease) | −4 |
| sspB | Cysteine protease | −3 |
| tst | Toxic shock syndrome toxin-1 | −5 |
a
Value represents the average fold change in gene expression as determined from two independent experiments comparing a nonhemolytic variant to wild-type FRI1169. Only genes identified in reference 25 as staphylococcal extracellular accessory proteins or regulatory genes whose expression was significantly altered are shown.