TABLE 1.
hrpA and hrpB genes in the sequenced meningococcal genomes
| Strain |
hrpA
|
hrpB
|
||||
|---|---|---|---|---|---|---|
| ORFa | Predicted protein length (aa) | % Identity (protein) to NMB1779 | ORF | Predicted protein length (aa) | % Identity (protein) to NMB1780 | |
| Z2491 | NMA0688 | 2,016 | 77.4 | NMA0687 | 580 | 98.6 |
| MC58 | NMB1779 | 1,995 | 100 | NMB1780 | 580 | 100 |
| NMB0497 | 1,976 | 93.5 | NMB0496b | 559 | 99.3 | |
| NMB0493 | 2,703 | 13.4 | −c | − | − | |
| NMB1214 | 2,274 | 16.0 | − | − | − | |
| NMB1768 | 2,514 | 13.9 | NMB1762 | 595 | 44.5 | |
| FAM18 | NMC0444 | 2,027 | 65.4 | NMC0443 | 580 | 99.0 |
a
NMA, NMB, and NMC denote the genes in strain Z2491, MC58, and FAM18 genomes (44), respectively, encoding proteins homologous to B. pertussis FhaB (HrpA in meningococci) and FhaC (HrpB in meningococci).
b
The protein encoded by NMB0496 lacks the first 21 aa at the N terminus and thus presumably contains no functional signal sequence.
c
−, not detected; genome of no associated putative hrpB gene could be detected in the MC58 for NMB0493 and NMB1214.