FIG. 8.

Diagrams produced with Ingenuity Systems, Inc., software show induced genes (shown in blue and identified by their HUGO symbols) involved in T- and B-cell receptor activation for each experimental group on day 25 (4 days postchallenge). Genes were selected to be included on all diagrams if they were induced twofold or more (P ≤ 0.01) in half of any experimental group or, in the case of the live vaccine, any subgroup (for the purpose of gene selection, this group was subdivided into two subgroups reflecting the range of pathology observed). Genes on these diagrams are connected if the relationship between the resulting proteins is activation, expression, binding regulation, or inhibition. Solid lines denote direct relationships, and dotted lines denote indirect relationships.